Complications of Diabetes Mellitus

Diabetes mellitus is one of the most widespread diseases in industrialized countries. Its macro- and microvascular complications lead to severe symptoms, mainly affecting the kidneys, the eyes, the peripheral nervous system and the heart. Since optimal blood glucose control is only achieved in a minority of patients, specific treatment options are needed which exert their effects despite hyperglycemia.

This book gives insights into pathophysiology and pathogenesis of diabetic complications. It shows a potential for pathogenetically-based therapeutic interventions which affect damaging pathways of glycolysis in

• diabetic nephropathy
• retinopathy
• neuropathy and
• diabetes-associated cardiovascular events.